The problem is that you must have a panorama first. Any program code can create one. There are some tools to stitch (right word?) pictures together. Photoshop or Gimp maybe. If you use a 3D program you can make a camera rotation (Cinema4d produce a Quicktime movie and a 360° picture), but if you make an illustrated game you have to draw it more or less. You can draw four sides and make a fake panorama with a cube.
But then you only have the picture. All actions and functions should be handmade in Visionaire this time.
I think, in a 2D game it is easy to make the backgrounds. That's why the stages are so beautiful in most cases. They are stills.
But making a simple walking animation isn't that easy. You have four options:
1. Drawing all frames by hand. It's old Disney school. Needs a very good artist.
2. Make a CG (3D) solution and use some filters (like
Sketch and Toon in C4d). You will see the difference between scene and character. But depends on the used style.
3. Make a CG solution and use it as background to draw by hand (that's what I prefer), f.e.with a light table. The style of characters and background is the same.
4. Use an 2D animation tool with bone rigging. I think it's a good compromise to maintain the art style, but I haven't test it.
edit: I forgot, this is a first person thread. So you have to animate the other characters only...